The Selective SIK2 Inhibitor ARN-3236 Produces Strong Antidepressant-Like Efficacy in Mice via the Hippocampal CRTC1-CREB-BDNF Pathway

The Selective SIK2 Inhibitor ARN-3236 Produces Strong Antidepressant-Like Efficacy in Mice via the Hippocampal CRTC1-CREB-BDNF Pathway

Depression is a widespread chronic medical illness affecting thoughts, mood, and physical health. However, the limited and delayed therapeutic efficacy of monoaminergic drugs has led to intensive research efforts to develop novel antidepressants. ARN-3236 is the first potent and selective inhibitor...

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Bibliographic Details
Main Authors: Yue Liu, Wenqian Tang, Chunhui Ji, Jianghong Gu, Yanmei Chen, Jie Huang, Xinyi Zhao, Yingfang Sun, Chengniu Wang, Wei Guan, Jianfeng Liu, Bo Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
ARN-3236
brain-derived neurotrophic factor
cyclic AMP response element binding protein
CREB-Regulated transcription coactivator 1
depression
hippocampus
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.624429/full

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https://www.frontiersin.org/articles/10.3389/fphar.2020.624429/full

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