RNA-seq analysis reveals significant transcriptome changes in huntingtin-null human neuroblastoma cells

RNA-seq analysis reveals significant transcriptome changes in huntingtin-null human neuroblastoma cells

Abstract Background Huntingtin (Htt) protein is the product of the gene mutated in Huntington’s disease (HD), a fatal, autosomal dominant, neurodegenerative disorder. Normal Htt is essential for early embryogenesis and the development of the central nervous system. However, the role of Htt in adult...

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Bibliographic Details
Main Authors: Johanna Bensalel, Hongyuan Xu, Michael L. Lu, Enrico Capobianco, Jianning Wei
Format: Article
Language:English
Published: BMC 2021-07-01
Series:BMC Medical Genomics
Subjects:
RNA-seq
Transcriptome
Huntingtin
Huntington’s disease
Knock out
CRISPR-Cas9
Online Access:https://doi.org/10.1186/s12920-021-01022-w

Internet

https://doi.org/10.1186/s12920-021-01022-w

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