Polyvinylpyrrolidone microneedles for localized delivery of sinomenine hydrochloride: preparation, release behavior of in vitro & in vivo, and penetration mechanism

Polyvinylpyrrolidone microneedles for localized delivery of sinomenine hydrochloride: preparation, release behavior of in vitro & in vivo, and penetration mechanism

Sinomenine (SIN) is an anti-inflammatory alkaloid derived from Sinomenium acutum, and the products sinomenine hydrochloride (SH) tablets and injections have been marketed in China to treat rheumatoid arthritis (RA). Oral administration of SH has shortcomings of gastrointestinal irritation and low bi...

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Bibliographic Details
Main Authors: Zixuan Shu, Yingji Cao, Yaotian Tao, Xiao Liang, Fangyuan Wang, Zhi Li, Zhenbao Li, Shuangying Gui
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Drug Delivery
Subjects:
sinomenine hydrochloride
dissolving microneedles
transdermal drug delivery system
microdialysis
fluorescent labeling
Online Access:http://dx.doi.org/10.1080/10717544.2020.1754524

Internet

http://dx.doi.org/10.1080/10717544.2020.1754524

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