The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity

The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity

<p>Abstract</p> <p>Background</p> <p>We characterized the biologic effects of a novel small molecule STAT3 pathway inhibitor that is derived from the natural product curcumin. We hypothesized this lead compound would specifically inhibit the STAT3 signaling pathway to i...

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Bibliographic Details
Main Authors: Young Gregory S, Fossey Stacey L, Hoyt Dale G, Lin Jiayuh, Abdelhamid Dalia, Schwartz Eric B, Benson Don M, Bakan Courtney, Yui Jennifer, Li Chenglong, Fuchs James R, Bill Matthew A, Carson William E, Li Pui-Kai, Lesinski Gregory B
Format: Article
Language:English
Published: BMC 2010-06-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/9/1/165

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http://www.molecular-cancer.com/content/9/1/165

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