Efficient Gene Knockout and Knockdown Systems in Neospora caninum Enable Rapid Discovery and Functional Assessment of Novel Proteins

Efficient Gene Knockout and Knockdown Systems in Neospora caninum Enable Rapid Discovery and Functional Assessment of Novel Proteins

ABSTRACT The development of molecular genetics has greatly enhanced the study of the biology and pathology associated with parasites of the phylum Apicomplexa. While the molecular tools are highly developed for the apicomplexan Toxoplasma gondii, the closely related parasite Neospora caninum lacks e...

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Bibliographic Details
Main Authors: Tiago W. P. Mineo, Jessica H. Chern, Amara C. Thind, Caroline M. Mota, Santhosh M. Nadipuram, Juan A. Torres, Peter J. Bradley
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:mSphere
Subjects:
Neospora caninum
Toxoplasma gondii
Ku80
CRISPR/Cas9
dense granule
auxin-inducible degron
Online Access:https://journals.asm.org/doi/10.1128/msphere.00896-21

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https://journals.asm.org/doi/10.1128/msphere.00896-21

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