Monocytes educated by cancer-associated fibroblasts secrete exosomal miR-181a to activate AKT signaling in breast cancer cells

Monocytes educated by cancer-associated fibroblasts secrete exosomal miR-181a to activate AKT signaling in breast cancer cells

Significance Cancer-associated fibroblasts (CAFs), as a major component of tumor stroma, affect tumor cell behavior in different manners. Even though it has been shown that CAFs support tumor growth, not much is known about how they contribute to immunosuppression in the tumor microenvironment (TME)...

Full description

Bibliographic Details
Main Authors: Katayoon Pakravan, Majid Mossahebi-Mohammadi, Mohammad H. Ghazimoradi, William C. Cho, Majid Sadeghizadeh, Sadegh Babashah
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Translational Medicine
Subjects:
Breast cancer
Cancer-associated fibroblasts
Tumor-associated macrophages
Immunosuppressive tumor microenvironment
Exosomes
AKT signaling
Online Access:https://doi.org/10.1186/s12967-022-03780-2

Internet

https://doi.org/10.1186/s12967-022-03780-2

Similar Items