Apurinic/Apyrimidinic Endonuclease 1 and Tyrosyl-DNA Phosphodiesterase 1 Prevent Suicidal Covalent DNA-Protein Crosslink at Apurinic/Apyrimidinic Site
Bifunctional 8-oxoguanine-DNA glycosylase (OGG1), a crucial DNA-repair enzyme, removes from DNA 8-oxo-7,8-dihydroguanine (8-oxoG) with following cleavage of the arising apurinic/apyrimidinic (AP) site. The major enzyme in eukaryotic cells that catalyzes the cleavage of AP sites is AP endonuclease 1...
| Main Authors: | , , , |
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| Format: | Article |
| Jezik: | English |
| Izdano: |
Frontiers Media S.A.
2021-01-01
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| Serija: | Frontiers in Cell and Developmental Biology |
| Teme: | |
| Online dostop: | https://www.frontiersin.org/articles/10.3389/fcell.2020.617301/full |