The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function

The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function

Oftedal et al. generate mice lacking the chaperonin subunit CCT8 in T cells. They find that loss of CCT8 leads to reduced formation of nuclear actin filaments, changes in proteostasis, defective Th2 cell polarization and T cell metabolism and a failed antigenic response to intestinal helminths.

Bibliographic Details
Main Authors: Bergithe E. Oftedal, Stefano Maio, Adam E. Handel, Madeleine P. J. White, Duncan Howie, Simon Davis, Nicolas Prevot, Ioanna A. Rota, Mary E. Deadman, Benedikt M. Kessler, Roman Fischer, Nikolaus S. Trede, Erdinc Sezgin, Rick M. Maizels, Georg A. Holländer
Format: Article
Language:English
Published: Nature Portfolio 2021-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02203-0

Internet

https://doi.org/10.1038/s42003-021-02203-0

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