Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization

Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization

Abstract Background Tumors are complex tissues containing collections of phenotypically diverse malignant and nonmalignant cells. We know little of the mechanisms that govern heterogeneity of tumor cells nor of the role heterogeneity plays in overcoming stresses, such as adaptation to different micr...

Full description

Bibliographic Details
Main Authors: Sanjana Rajan, Emily M. Franz, Camille A. McAloney, Tatyana A. Vetter, Maren Cam, Amy C. Gross, Cenny Taslim, Meng Wang, Matthew V. Cannon, Alexander Oles, Ryan D. Roberts
Format: Article
Language:English
Published: BMC 2023-04-01
Series:BMC Biology
Subjects:
Osteosarcoma
Heterogeneity
Transcriptional profile
Clonal selection
Microenvironment
Metastasis
Online Access:https://doi.org/10.1186/s12915-023-01593-3

Internet

https://doi.org/10.1186/s12915-023-01593-3

Similar Items