First Crystal Structure of Bacterial Oligopeptidase B in an Intermediate State: The Roles of the Hinge Region Modification and Spermine

First Crystal Structure of Bacterial Oligopeptidase B in an Intermediate State: The Roles of the Hinge Region Modification and Spermine

Oligopeptidase B (OpB) is a two-domain, trypsin-like serine peptidase belonging to the S9 prolyloligopeptidase (POP) family. Two domains are linked by a hinge region that participates in the transition of the enzyme between two major states—closed and open—in which domains and residues of the cataly...

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Bibliographic Details
Main Authors: Dmitry E. Petrenko, Vladimir I. Timofeev, Vladimir V. Britikov, Elena V. Britikova, Sergey Y. Kleymenov, Anna V. Vlaskina, Inna P. Kuranova, Anna G. Mikhailova, Tatiana V. Rakitina
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Biology
Subjects:
prolyloligopeptidase
oligopeptidase B
<i>Serratia proteomaculans</i>
crystal structure
intermediate state
hinge region
Online Access:https://www.mdpi.com/2079-7737/10/10/1021

Internet

https://www.mdpi.com/2079-7737/10/10/1021

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