Targeted Liposomes Encapsulating miR-603 Complexes Enhance Radiation Sensitivity of Patient-Derived Glioblastoma Stem-Like Cells

Targeted Liposomes Encapsulating miR-603 Complexes Enhance Radiation Sensitivity of Patient-Derived Glioblastoma Stem-Like Cells

Despite potential for clinical efficacy, therapeutic delivery of microRNAs (miRNA) remains a major translational barrier. Here, we explore a strategy for miRNA delivery in the treatment of glioblastoma, the most common form of adult brain cancer, that involves complexation of miRNA with polyethyleni...

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Bibliographic Details
Main Authors: Ahmed M. Shabana, Beibei Xu, Zachary Schneiderman, Jun Ma, Clark C. Chen, Efrosini Kokkoli
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceutics
Subjects:
stealth liposomes
microRNA delivery
targeting integrin α<sub>5</sub>β<sub>1</sub>
miR-603
glioblastoma stem-cell state
radiation therapy
Online Access:https://www.mdpi.com/1999-4923/13/8/1115

Internet

https://www.mdpi.com/1999-4923/13/8/1115

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