Links Between Metabolic and Structural Changes in the Brain of Cognitively Normal Older Adults: A 4-Year Longitudinal Follow-Up

Links Between Metabolic and Structural Changes in the Brain of Cognitively Normal Older Adults: A 4-Year Longitudinal Follow-Up

We aimed to longitudinally assess the relationship between changing brain energy metabolism (glucose and acetoacetate) and cognition during healthy aging. Participants aged 71 ± 5 year underwent cognitive evaluation and quantitative positron emission tomography (PET) and magnetic resonance imaging (...

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Bibliographic Details
Main Authors: Christian-Alexandre Castellano, Carol Hudon, Etienne Croteau, Mélanie Fortier, Valérie St-Pierre, Camille Vandenberghe, Scott Nugent, Sébastien Tremblay, Nancy Paquet, Martin Lepage, Tamàs Fülöp, Éric E. Turcotte, Isabelle J. Dionne, Olivier Potvin, Simon Duchesne, Stephen C. Cunnane
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
aging
brain energy metabolism
cognition
glucose
insulin resistance
ketones
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00015/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2019.00015/full

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