The CaMK4/CREB/IRS-2 cascade stimulates proliferation and inhibits apoptosis of β-cells.

The CaMK4/CREB/IRS-2 cascade stimulates proliferation and inhibits apoptosis of β-cells.

Progressive reduction in β-cell mass is responsible for the development of type 2 diabetes mellitus, and alteration in insulin receptor substrate 2 (IRS-2) abundance plays a critical role in this process. IRS-2 expression is stimulated by the transcription factor cAMP response element-binding protei...

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Bibliographic Details
Main Authors: Bo Liu, Helena Barbosa-Sampaio, Peter M Jones, Shanta J Persaud, Dany S Muller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23049845/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23049845/?tool=EBI

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