Synthesis of Xylitan Derivatives and Preliminary Evaluation of in Vitro Trypanocidal Activity

Synthesis of Xylitan Derivatives and Preliminary Evaluation of in Vitro Trypanocidal Activity

A series of novel xylitan derivatives derived from xylitol were synthesized using operationally simple procedures. A xylitan acetonide was the key intermediate used to prepare benzoate, arylsulfonate esters and 1,2,3-triazole derivatives of xylitan. These compounds were evaluated for their in vitro...

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Bibliographic Details
Main Authors: Paula Regina Elias, Gleicekelly Silva Coelho, Viviane Flores Xavier, Policarpo Ademar Sales Junior, Alvaro José Romanha, Silvane Maria Fonseca Murta, Claudia Martins Carneiro, Nilton Soares Camilo, Flaviane Francisco Hilário, Jason Guy Taylor
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:Molecules
Subjects:
xylitan
xylitol
anhydropentitol
amastigote
trypomastigote
in vitro
chagas disease
Online Access:http://www.mdpi.com/1420-3049/21/10/1342

Internet

http://www.mdpi.com/1420-3049/21/10/1342

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