SGLT2 Inhibitors May Restore Endothelial Barrier Interrupted by 25-Hydroxycholesterol

SGLT2 Inhibitors May Restore Endothelial Barrier Interrupted by 25-Hydroxycholesterol

SGLT2 (Sodium-glucose Cotransporter-2) inhibitors are newer glucose-lowering drugs with many cardiovascular benefits that are not fully understood yet. Endothelial integrity plays a key role in cardiovascular homeostasis. 25-hydroxycholesterol (25-OHC), which is a proatherogenic stimuli that impairs...

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Bibliographic Details
Main Authors: Agnieszka Pawlos, Marlena Broncel, Ewelina Woźniak, Łukasz Markiewicz, Agnieszka Piastowska-Ciesielska, Paulina Gorzelak-Pabiś
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
SGLT2i
endothelial integrity
endothelial barrier
VE-cadherin
empagliflozin
canagliflozin
Online Access:https://www.mdpi.com/1420-3049/28/3/1112

Internet

https://www.mdpi.com/1420-3049/28/3/1112

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