SPOP inhibits BRAF-dependent tumorigenesis through promoting non-degradative ubiquitination of BRAF

SPOP inhibits BRAF-dependent tumorigenesis through promoting non-degradative ubiquitination of BRAF

Abstract Background The gene encoding the E3 ubiquitin ligase substrate-binding adapter Speckle-type BTB/POZ protein (SPOP) is frequently mutated in prostate cancer (PCa) and endometrial cancer (EC); however, the molecular mechanisms underlying the contribution of SPOP mutations to tumorigenesis rem...

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Bibliographic Details
Main Authors: Kai Feng, Qing Shi, Dongyue Jiao, Yingji Chen, Wanqi Yang, Ke Su, Yalan Wang, Yan Huang, Pingzhao Zhang, Yao Li, Chenji Wang
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Cell & Bioscience
Subjects:
SPOP
BRAF
Mutation
Ubiquitination
MAPK/ERK
Online Access:https://doi.org/10.1186/s13578-022-00950-z

Internet

https://doi.org/10.1186/s13578-022-00950-z

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