NOX4 Mediates Epithelial Cell Death in Hyperoxic Acute Lung Injury Through Mitochondrial Reactive Oxygen Species

NOX4 Mediates Epithelial Cell Death in Hyperoxic Acute Lung Injury Through Mitochondrial Reactive Oxygen Species

Management of acute respiratory distress involves O2 supplementation, which is lifesaving, but causes severe hyperoxic acute lung injury (HALI). NADPH oxidase (NOX) could be a major source of reactive oxygen species (ROS) in hyperoxia (HO). Epithelial cell death is a crucial step in the development...

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Bibliographic Details
Main Authors: Anantha Harijith, Prathima Basa, Alison Ha, Jaya Thomas, Anjum Jafri, Panfeng Fu, Peter M. MacFarlane, Thomas M. Raffay, Viswanathan Natarajan, Tara Sudhadevi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
NADPH oxidase 4
mitochondrial ROS
alveolar type 2 epithelial cell
apoptosis
hyperoxic acute lung injury
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.880878/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.880878/full

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