The Altered Functions of Shelterin Components in ALT Cells

The Altered Functions of Shelterin Components in ALT Cells

Telomeres are nucleoprotein complexes that cap the ends of eukaryotic linear chromosomes. Telomeric DNA is bound by shelterin protein complex to prevent telomeric chromosome ends from being recognized as damaged sites for abnormal repair. To overcome the end replication problem, cancer cells mostly...

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Bibliographic Details
Main Authors: Yanduo Zhang, Kailong Hou, Jinkai Tong, Haonan Zhang, Mengjie Xiong, Jing Liu, Shuting Jia
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
telomere
shelterin
replication stress
DNA replication
DNA repair
Online Access:https://www.mdpi.com/1422-0067/24/23/16830

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https://www.mdpi.com/1422-0067/24/23/16830

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