Response Type and Host Species may be Sufficient to Predict Dose-Response Curve Shape for Adenoviral Vector Vaccines
Vaccine dose-response curves can follow both saturating and peaking shapes. Dose-response curves for adenoviral vector vaccines have not been systematically described. In this paper, we explore the dose-response shape of published adenoviral animal and human studies. Where data were informative, dos...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/8/2/155 |
| _version_ | 1797571916663357440 |
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| author | John Benest Sophie Rhodes Sara Afrough Thomas Evans Richard White |
| author_facet | John Benest Sophie Rhodes Sara Afrough Thomas Evans Richard White |
| author_sort | John Benest |
| collection | DOAJ |
| description | Vaccine dose-response curves can follow both saturating and peaking shapes. Dose-response curves for adenoviral vector vaccines have not been systematically described. In this paper, we explore the dose-response shape of published adenoviral animal and human studies. Where data were informative, dose-response was approximately five times more likely to be peaking than saturating. There was evidence that host species and response type may be sufficient for prediction of dose-response curve shape. Dose-response curve shape prediction could decrease clinical trial costs, accelerating the development of life-saving vaccines. |
| first_indexed | 2024-03-10T20:48:22Z |
| format | Article |
| id | doaj.art-f3cecadde93f4e44ba1484ca865aa33e |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T20:48:22Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-f3cecadde93f4e44ba1484ca865aa33e2023-11-19T20:12:04ZengMDPI AGVaccines2076-393X2020-03-018215510.3390/vaccines8020155Response Type and Host Species may be Sufficient to Predict Dose-Response Curve Shape for Adenoviral Vector VaccinesJohn Benest0Sophie Rhodes1Sara Afrough2Thomas Evans3Richard White4Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UKDepartment of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UKVaccitech Ltd., The Schrodinger Building, Heatley Road, The Oxford Science Park, Oxford OX4 4GE, UKVaccitech Ltd., The Schrodinger Building, Heatley Road, The Oxford Science Park, Oxford OX4 4GE, UKDepartment of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UKVaccine dose-response curves can follow both saturating and peaking shapes. Dose-response curves for adenoviral vector vaccines have not been systematically described. In this paper, we explore the dose-response shape of published adenoviral animal and human studies. Where data were informative, dose-response was approximately five times more likely to be peaking than saturating. There was evidence that host species and response type may be sufficient for prediction of dose-response curve shape. Dose-response curve shape prediction could decrease clinical trial costs, accelerating the development of life-saving vaccines.https://www.mdpi.com/2076-393X/8/2/155dosingdose-responseadenovirus-vectored vaccinesdose dynamics |
| spellingShingle | John Benest Sophie Rhodes Sara Afrough Thomas Evans Richard White Response Type and Host Species may be Sufficient to Predict Dose-Response Curve Shape for Adenoviral Vector Vaccines Vaccines dosing dose-response adenovirus-vectored vaccines dose dynamics |
| title | Response Type and Host Species may be Sufficient to Predict Dose-Response Curve Shape for Adenoviral Vector Vaccines |
| title_full | Response Type and Host Species may be Sufficient to Predict Dose-Response Curve Shape for Adenoviral Vector Vaccines |
| title_fullStr | Response Type and Host Species may be Sufficient to Predict Dose-Response Curve Shape for Adenoviral Vector Vaccines |
| title_full_unstemmed | Response Type and Host Species may be Sufficient to Predict Dose-Response Curve Shape for Adenoviral Vector Vaccines |
| title_short | Response Type and Host Species may be Sufficient to Predict Dose-Response Curve Shape for Adenoviral Vector Vaccines |
| title_sort | response type and host species may be sufficient to predict dose response curve shape for adenoviral vector vaccines |
| topic | dosing dose-response adenovirus-vectored vaccines dose dynamics |
| url | https://www.mdpi.com/2076-393X/8/2/155 |
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