Detection of Structural Variations and Fusion Genes in Breast Cancer Samples Using Third-Generation Sequencing

Detection of Structural Variations and Fusion Genes in Breast Cancer Samples Using Third-Generation Sequencing

Background: Structural variations (SVs) are common genetic alterations in the human genome that could cause different phenotypes and diseases, including cancer. However, the detection of structural variations using the second-generation sequencing was limited by its short read length, which restrain...

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Bibliographic Details
Main Authors: Taobo Hu, Jingjing Li, Mengping Long, Jinbo Wu, Zhen Zhang, Fei Xie, Jin Zhao, Houpu Yang, Qianqian Song, Sheng Lian, Jiandong Shi, Xueyu Guo, Daoli Yuan, Dandan Lang, Guoliang Yu, Baosheng Liang, Xiaohua Zhou, Toyotaka Ishibashi, Xiaodan Fan, Weichuan Yu, Depeng Wang, Yang Wang, I-Feng Peng, Shu Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
long-read sequencing
breast cancer
structural variation
fusion gene
sequencing panel
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.854640/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.854640/full

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