Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides

Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides

Abstract Antimicrobial peptides (AMPs) are important mediators of intestinal immune surveillance. However, the regional heterogeneity of AMPs and its regulatory mechanisms remain obscure. Here, we clarified the regional heterogeneity of intestinal AMPs at the single-cell level, and revealed a cross-...

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Bibliographic Details
Main Authors: Yue Wang, Yanbo Yu, Lixiang Li, Mengqi Zheng, Jiawei Zhou, Haifan Gong, Bingcheng Feng, Xiao Wang, Xuanlin Meng, Yanyan Cui, Yanan Xia, Shuzheng Chu, Lin Lin, Huijun Chang, Ruchen Zhou, Mingjun Ma, Zhen Li, Rui Ji, Ming Lu, Xiaoyun Yang, Xiuli Zuo, Shiyang Li, Yanqing Li
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40565-7

Internet

https://doi.org/10.1038/s41467-023-40565-7

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