Myelodysplastic syndromes are multiclonal diseases derived from hematopoietic stem and progenitor cells

Myelodysplastic syndromes are multiclonal diseases derived from hematopoietic stem and progenitor cells

Abstract Myelodysplastic syndromes (MDS) are generally considered as a group of clonal diseases derived from hematopoietic stem cells, but a number of studies have suggested that they are derived from myeloid progenitor cells. We aimed to identify the cell of origin in MDS by single-cell analyses. T...

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Bibliographic Details
Main Authors: Bingqing Luo, Fang Dong, Tiejun Qin, Qingyun Zhang, Haitao Bai, Jinhong Wang, Yujiao Jia, Shihui Ma, Erlie Jiang, Tao Cheng, Zhijian Xiao, Hideo Ema
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Experimental Hematology & Oncology
Subjects:
Myelodysplastic syndromes (MDS)
Clonal hematopoiesis (CH)
Cell of origin
Hematopoietic stem cells (HSCs)
Hematopoietic progenitor cells (HPCs)
Single-cell analysis
Online Access:https://doi.org/10.1186/s40164-022-00280-3

Internet

https://doi.org/10.1186/s40164-022-00280-3

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