The immunosuppressive properties of the HIV Vpr protein are linked to a single highly conserved residue, R90.

The immunosuppressive properties of the HIV Vpr protein are linked to a single highly conserved residue, R90.

BACKGROUND: A hallmark of AIDS progression is a switch of cytokines from Th1 to Th2 in the plasma of patients. IL-12, a critical Th1 cytokine secreted by antigen presenting cells (APCs) is suppressed by Vpr, implicating it as an important virulence factor. We hypothesize that Vpr protein packaged in...

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Bibliographic Details
Main Authors: Irina Tcherepanova, Aijing Starr, Brad Lackford, Melissa D Adams, Jean-Pierre Routy, Mohamed Rachid Boulassel, David Calderhead, Don Healey, Charles Nicolette
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2689350?pdf=render

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http://europepmc.org/articles/PMC2689350?pdf=render

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