Peptide/β-Peptoid Hybrids with Ultrashort PEG-Like Moieties: Effects on Hydrophobicity, Antibacterial Activity and Hemolytic Properties

Peptide/β-Peptoid Hybrids with Ultrashort PEG-Like Moieties: Effects on Hydrophobicity, Antibacterial Activity and Hemolytic Properties

PEGylation of antimicrobial peptides as a shielding tool that increases stability toward proteolytic degradation typically leads to concomitant loss of activity, whereas incorporation of ultrashort PEG-like amino acids (sPEGs) remains essentially unexplored. Here, modification of a peptide/β-peptoid...

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Bibliographic Details
Main Authors: Nicki Frederiksen, Stavroula Louka, Chirag Mudaliar, Ilona Domraceva, Agrita Kreicberga, Osvalds Pugovics, Dorota Żabicka, Magdalena Tomczak, Weronika Wygoda, Fredrik Björkling, Henrik Franzyk
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
peptidomimetics
ultrashort PEG-like moieties
hydrophobicity
antibacterial activity
hemolysis
HepG2 cell viability
Online Access:https://www.mdpi.com/1422-0067/22/13/7041

Internet

https://www.mdpi.com/1422-0067/22/13/7041

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