Synthesis and Antiproliferative Activity of 2,5-bis(3′-Indolyl)pyrroles, Analogues of the Marine Alkaloid Nortopsentin

Synthesis and Antiproliferative Activity of 2,5-bis(3′-Indolyl)pyrroles, Analogues of the Marine Alkaloid Nortopsentin

2,5-bis(3′-Indolyl)pyrroles, analogues of the marine alkaloid nortopsentin, were conveniently prepared through a three step procedure in good overall yields. Derivatives 1a and 1b exhibited concentration-dependent antitumor activity towards a panel of 42 human tumor cell lines with mean IC50 values...

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Bibliographic Details
Main Authors: Gerhard Kelter, Armin Maier, Patrizia Diana, Girolamo Cirrincione, Virginia Spanò, Paola Barraja, Barbara Parrino, Anna Carbone, Heinz-Herbert Fiebig
Format: Article
Language:English
Published: MDPI AG 2013-03-01
Series:Marine Drugs
Subjects:
bis-indolyl-pyrroles
nortopsentin analogues
marine alkaloids
antitumor
ex-vivo xenografts
Online Access:http://www.mdpi.com/1660-3397/11/3/643

Internet

http://www.mdpi.com/1660-3397/11/3/643

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