ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells

ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells

The metastability of stem cells requires a mechanism for actively blocking dedifferentiation to achieve successful differentiation. Here the authors show that ZBTB12 serves as a molecular barrier to dedifferentiation by repressing a primate-specific retrotransposon, HERVH.

Bibliographic Details
Main Authors: Dasol Han, Guojing Liu, Yujeong Oh, Seyoun Oh, Seungbok Yang, Lori Mandjikian, Neha Rani, Maria C. Almeida, Kenneth S. Kosik, Jiwon Jang
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36178-9

Internet

https://doi.org/10.1038/s41467-023-36178-9

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