ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells
The metastability of stem cells requires a mechanism for actively blocking dedifferentiation to achieve successful differentiation. Here the authors show that ZBTB12 serves as a molecular barrier to dedifferentiation by repressing a primate-specific retrotransposon, HERVH.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36178-9 |
| _version_ | 1811165808441688064 |
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| author | Dasol Han Guojing Liu Yujeong Oh Seyoun Oh Seungbok Yang Lori Mandjikian Neha Rani Maria C. Almeida Kenneth S. Kosik Jiwon Jang |
| author_facet | Dasol Han Guojing Liu Yujeong Oh Seyoun Oh Seungbok Yang Lori Mandjikian Neha Rani Maria C. Almeida Kenneth S. Kosik Jiwon Jang |
| author_sort | Dasol Han |
| collection | DOAJ |
| description | The metastability of stem cells requires a mechanism for actively blocking dedifferentiation to achieve successful differentiation. Here the authors show that ZBTB12 serves as a molecular barrier to dedifferentiation by repressing a primate-specific retrotransposon, HERVH. |
| first_indexed | 2024-04-10T15:43:44Z |
| format | Article |
| id | doaj.art-f3e07482fc9142a28b133dbf0b354992 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T15:43:44Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f3e07482fc9142a28b133dbf0b3549922023-02-12T12:17:27ZengNature PortfolioNature Communications2041-17232023-02-0114111610.1038/s41467-023-36178-9ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cellsDasol Han0Guojing Liu1Yujeong Oh2Seyoun Oh3Seungbok Yang4Lori Mandjikian5Neha Rani6Maria C. Almeida7Kenneth S. Kosik8Jiwon Jang9Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of CaliforniaNeuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of CaliforniaDepartment of Life Sciences, Pohang University of Science and Technology (POSTECH)Department of Life Sciences, Pohang University of Science and Technology (POSTECH)Department of Life Sciences, Pohang University of Science and Technology (POSTECH)Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of CaliforniaNeuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of CaliforniaNeuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of CaliforniaNeuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of CaliforniaDepartment of Life Sciences, Pohang University of Science and Technology (POSTECH)The metastability of stem cells requires a mechanism for actively blocking dedifferentiation to achieve successful differentiation. Here the authors show that ZBTB12 serves as a molecular barrier to dedifferentiation by repressing a primate-specific retrotransposon, HERVH.https://doi.org/10.1038/s41467-023-36178-9 |
| spellingShingle | Dasol Han Guojing Liu Yujeong Oh Seyoun Oh Seungbok Yang Lori Mandjikian Neha Rani Maria C. Almeida Kenneth S. Kosik Jiwon Jang ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells Nature Communications |
| title | ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells |
| title_full | ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells |
| title_fullStr | ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells |
| title_full_unstemmed | ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells |
| title_short | ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells |
| title_sort | zbtb12 is a molecular barrier to dedifferentiation in human pluripotent stem cells |
| url | https://doi.org/10.1038/s41467-023-36178-9 |
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