Noninvasive Diagnosis of the Mitochondrial Function of Doxorubicin-Induced Cardiomyopathy Using In Vivo Dynamic Nuclear Polarization–Magnetic Resonance Imaging

Noninvasive Diagnosis of the Mitochondrial Function of Doxorubicin-Induced Cardiomyopathy Using In Vivo Dynamic Nuclear Polarization–Magnetic Resonance Imaging

Doxorubicin (DOX) induces dose-dependent cardiotoxicity via oxidative stress and abnormal mitochondrial function in the myocardium. Therefore, a noninvasive in vivo imaging procedure for monitoring the redox status of the heart may aid in monitoring diseases and developing treatments. However, an ap...

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Bibliographic Details
Main Authors: Yukie Mizuta, Tomohiko Akahoshi, Hinako Eto, Fuminori Hyodo, Masaharu Murata, Kentaro Tokuda, Masatoshi Eto, Ken Yamaura
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Antioxidants
Subjects:
dynamic nuclear polarization–magnetic resonance imaging
oxidation reduction
mitochondria
nitroxyl radical
heart
Online Access:https://www.mdpi.com/2076-3921/11/8/1454

Internet

https://www.mdpi.com/2076-3921/11/8/1454

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