Diffuse noxious inhibitory controls in chronic joint inflammatory Pain: Study of the descending serotonergic modulation mediated through 5HT3 receptors

Diffuse noxious inhibitory controls in chronic joint inflammatory Pain: Study of the descending serotonergic modulation mediated through 5HT3 receptors

The loss of diffuse noxious inhibitory controls (DNIC) is recognized as a predictor of chronic pain. Mechanistically, DNIC produces analgesia by a heterotopically applied conditioning-noxious stimulus (CS) and yet underexplored descending modulatory inputs. Here, we aimed at studying DNIC in monoart...

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Bibliographic Details
Main Authors: Raquel Pereira-Silva, Paula Serrão, Fani Lourença Neto, Isabel Martins
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Neurobiology of Pain
Subjects:
Chronic inflammatory joint pain
Descending serotonergic pain modulation
Diffuse noxious inhibitory controls
Spinal 5-hydroxytryptamine 3 receptors
Rostral ventromedial medulla
Online Access:http://www.sciencedirect.com/science/article/pii/S2452073X23000107

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http://www.sciencedirect.com/science/article/pii/S2452073X23000107

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