Structure determinants defining the specificity of papain-like cysteine proteases

Structure determinants defining the specificity of papain-like cysteine proteases

Papain-like cysteine proteases are widely expressed enzymes that mostly regulate protein turnover in the acidic conditions of lysosomes. However, in the last twenty years, these proteases have been evidenced to exert specific functions within different organelles as well as outside the cell. The mos...

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Bibliographic Details
Main Authors: Anastasiia I. Petushkova, Lyudmila V. Savvateeva, Andrey A. Zamyatnin, Jr
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Papain-like cysteine protease
Cysteine cathepsin
Protease specificity
Binding site
Selective inhibitor
Protein engineering
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022005347

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http://www.sciencedirect.com/science/article/pii/S2001037022005347

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