MSC exosomes attenuate sterile inflammation and necroptosis associated with TAK1-pJNK-NFKB mediated cardiomyopathy in diabetic ApoE KO mice

MSC exosomes attenuate sterile inflammation and necroptosis associated with TAK1-pJNK-NFKB mediated cardiomyopathy in diabetic ApoE KO mice

IntroductionDiabetes is a debilitating disease that leads to complications like cardiac dysfunction and heart failure. In this study, we investigated the pathophysiology of diabetes-induced cardiac dysfunction in mice with dyslipidemia. We hypothesize diabetes in ApoE knockout (ApoE-/-) mice induces...

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Bibliographic Details
Main Authors: Abha Banerjee, Dinender K. Singla
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
inflammation
cell death
diabetes cardiac dysfunction
exosomes
necroinflammation
dyslipidemia
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1348043/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1348043/full

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