MSC exosomes attenuate sterile inflammation and necroptosis associated with TAK1-pJNK-NFKB mediated cardiomyopathy in diabetic ApoE KO mice

MSC exosomes attenuate sterile inflammation and necroptosis associated with TAK1-pJNK-NFKB mediated cardiomyopathy in diabetic ApoE KO mice

IntroductionDiabetes is a debilitating disease that leads to complications like cardiac dysfunction and heart failure. In this study, we investigated the pathophysiology of diabetes-induced cardiac dysfunction in mice with dyslipidemia. We hypothesize diabetes in ApoE knockout (ApoE-/-) mice induces...

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Bibliographic Details
Main Authors:	Abha Banerjee, Dinender K. Singla
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Series:	Frontiers in Immunology
Subjects:	inflammation cell death diabetes cardiac dysfunction exosomes necroinflammation dyslipidemia
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1348043/full

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