Inflammatory signaling in NASH driven by hepatocyte mitochondrial dysfunctions

Inflammatory signaling in NASH driven by hepatocyte mitochondrial dysfunctions

Abstract Liver steatosis, inflammation, and variable degrees of fibrosis are the pathological manifestations of nonalcoholic steatohepatitis (NASH), an aggressive presentation of the most prevalent chronic liver disease in the Western world known as nonalcoholic fatty liver (NAFL). Mitochondrial hep...

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Bibliographic Details
Main Authors: Melissa Myint, Francesca Oppedisano, Valeria De Giorgi, Byeong-Moo Kim, Francesco M. Marincola, Harvey J. Alter, Salvatore Nesci
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Translational Medicine
Subjects:
NASH
Mitochondrial dysfunction
Ox-mtDNA
Inflammatory process
Hepatic stellate cells
Online Access:https://doi.org/10.1186/s12967-023-04627-0

Internet

https://doi.org/10.1186/s12967-023-04627-0

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