Bisphosphonate conjugation enhances the bone-specificity of NELL-1-based systemic therapy for spaceflight-induced bone loss in mice

Bisphosphonate conjugation enhances the bone-specificity of NELL-1-based systemic therapy for spaceflight-induced bone loss in mice

Abstract Microgravity-induced bone loss results in a 1% bone mineral density loss monthly and can be a mission critical factor in long-duration spaceflight. Biomolecular therapies with dual osteogenic and anti-resorptive functions are promising for treating extreme osteoporosis. We previously confir...

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Bibliographic Details
Main Authors: Pin Ha, Jin Hee Kwak, Yulong Zhang, Jiayu Shi, Luan Tran, Timothy Pan Liu, Hsin-Chuan Pan, Samantha Lee, Jong Kil Kim, Eric Chen, Yasaman Shirazi-Fard, Louis S. Stodieck, Andy Lin, Zhong Zheng, Stella Nuo Dong, Xinli Zhang, Benjamin M. Wu, Kang Ting, Chia Soo
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:npj Microgravity
Online Access:https://doi.org/10.1038/s41526-023-00319-7

Internet

https://doi.org/10.1038/s41526-023-00319-7

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