Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes

Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes

Abstract UBA1 is the primary E1 ubiquitin-activating enzyme responsible for generation of activated ubiquitin required for ubiquitination, a process that regulates stability and function of numerous proteins. Decreased or insufficient ubiquitination can cause or drive aging and many diseases. Theref...

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Manylion Llyfryddiaeth
Prif Awduron: Wenjing Yan, Yongwang Zhong, Xin Hu, Tuan Xu, Yinghua Zhang, Stephen Kales, Yanyan Qu, Daniel C. Talley, Bolormaa Baljinnyam, Christopher A. LeClair, Anton Simeonov, Brian M. Polster, Ruili Huang, Yihong Ye, Ganesha Rai, Mark J. Henderson, Dingyin Tao, Shengyun Fang
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Nature Portfolio 2023-08-01
Cyfres:Nature Communications
Mynediad Ar-lein:https://doi.org/10.1038/s41467-023-40537-x

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https://doi.org/10.1038/s41467-023-40537-x

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