Differential Impact of Severity and Duration of Status Epilepticus, Medical Countermeasures, and a Disease-Modifier, Saracatinib, on Brain Regions in the Rat Diisopropylfluorophosphate Model

Differential Impact of Severity and Duration of Status Epilepticus, Medical Countermeasures, and a Disease-Modifier, Saracatinib, on Brain Regions in the Rat Diisopropylfluorophosphate Model

Acute organophosphate (OP) toxicity poses a significant threat to both military and civilian personnel as it can lead to a variety of cholinergic symptoms including the development of status epilepticus (SE). Depending on its severity, SE can lead to a spectrum of neurological changes including neur...

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Bibliographic Details
Main Authors: Meghan Gage, Marson Putra, Crystal Gomez-Estrada, Madison Golden, Logan Wachter, Megan Gard, Thimmasettappa Thippeswamy
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
organophosphate toxicity
status epilepticus severity
gliosis
neurodegeneration
disease mitigation
saracatinib (AZD0530)
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.772868/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.772868/full

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