Use of VacA as a Vaccine Antigen
One of the major toxins secreted by H. pylori is the Vacuolating cytotoxin A (VacA) named after its ability to induce the formation of “vacuole”-like membrane vesicles in the cytoplasm of gastric cells. VacA has been associated with the disruption of mitochondrial functions, stimulation of apoptosis...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-06-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6651/8/6/181 |
| _version_ | 1811304578058027008 |
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| author | Mati Moyat Dominique Velin |
| author_facet | Mati Moyat Dominique Velin |
| author_sort | Mati Moyat |
| collection | DOAJ |
| description | One of the major toxins secreted by H. pylori is the Vacuolating cytotoxin A (VacA) named after its ability to induce the formation of “vacuole”-like membrane vesicles in the cytoplasm of gastric cells. VacA has been associated with the disruption of mitochondrial functions, stimulation of apoptosis, blockade of T cell proliferation and promotion of regulatory T cells, thereby making it a promising vaccine target. Immunity to bacterial virulence factors is well known to protect humans against bacterial infections; hence, detoxified VacA has been evaluated as a vaccine antigen. Our short review summarizes the pre-clinical and clinical data that have been published on the use of VacA in the development of the H. pylori vaccine. |
| first_indexed | 2024-04-13T08:09:45Z |
| format | Article |
| id | doaj.art-f3fd277331cb45b9b9ab36b0eccea3be |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-13T08:09:45Z |
| publishDate | 2016-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-f3fd277331cb45b9b9ab36b0eccea3be2022-12-22T02:55:03ZengMDPI AGToxins2072-66512016-06-018618110.3390/toxins8060181toxins8060181Use of VacA as a Vaccine AntigenMati Moyat0Dominique Velin1Service of Gastroenterology and Hepatology, Department of Medicine, Lausanne University Hospital, CLE D203, CHUV, 155 Chemin des Boveresses, CH-1066 Epalinges, SwitzerlandService of Gastroenterology and Hepatology, Department of Medicine, Lausanne University Hospital, CLE D203, CHUV, 155 Chemin des Boveresses, CH-1066 Epalinges, SwitzerlandOne of the major toxins secreted by H. pylori is the Vacuolating cytotoxin A (VacA) named after its ability to induce the formation of “vacuole”-like membrane vesicles in the cytoplasm of gastric cells. VacA has been associated with the disruption of mitochondrial functions, stimulation of apoptosis, blockade of T cell proliferation and promotion of regulatory T cells, thereby making it a promising vaccine target. Immunity to bacterial virulence factors is well known to protect humans against bacterial infections; hence, detoxified VacA has been evaluated as a vaccine antigen. Our short review summarizes the pre-clinical and clinical data that have been published on the use of VacA in the development of the H. pylori vaccine.http://www.mdpi.com/2072-6651/8/6/181VacAvaccineH. pylori |
| spellingShingle | Mati Moyat Dominique Velin Use of VacA as a Vaccine Antigen Toxins VacA vaccine H. pylori |
| title | Use of VacA as a Vaccine Antigen |
| title_full | Use of VacA as a Vaccine Antigen |
| title_fullStr | Use of VacA as a Vaccine Antigen |
| title_full_unstemmed | Use of VacA as a Vaccine Antigen |
| title_short | Use of VacA as a Vaccine Antigen |
| title_sort | use of vaca as a vaccine antigen |
| topic | VacA vaccine H. pylori |
| url | http://www.mdpi.com/2072-6651/8/6/181 |
| work_keys_str_mv | AT matimoyat useofvacaasavaccineantigen AT dominiquevelin useofvacaasavaccineantigen |