Pathway Evolution Through a Bottlenecking‐Debottlenecking Strategy and Machine Learning‐Aided Flux Balancing

Pathway Evolution Through a Bottlenecking‐Debottlenecking Strategy and Machine Learning‐Aided Flux Balancing

Abstract The evolution of pathway enzymes enhances the biosynthesis of high‐value chemicals, crucial for pharmaceutical, and agrochemical applications. However, unpredictable evolutionary landscapes of pathway genes often hinder successful evolution. Here, the presence of complex epistasis is identi...

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Bibliographic Details
Main Authors: Huaxiang Deng, Han Yu, Yanwu Deng, Yulan Qiu, Feifei Li, Xinran Wang, Jiahui He, Weiyue Liang, Yunquan Lan, Longjiang Qiao, Zhiyu Zhang, Yunfeng Zhang, Jay D. Keasling, Xiaozhou Luo
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Advanced Science
Subjects:
biofoundry
directed evolution
machine learning
pathway debottlenecking
Online Access:https://doi.org/10.1002/advs.202306935

Internet

https://doi.org/10.1002/advs.202306935

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