Pathway Evolution Through a Bottlenecking‐Debottlenecking Strategy and Machine Learning‐Aided Flux Balancing
Abstract The evolution of pathway enzymes enhances the biosynthesis of high‐value chemicals, crucial for pharmaceutical, and agrochemical applications. However, unpredictable evolutionary landscapes of pathway genes often hinder successful evolution. Here, the presence of complex epistasis is identi...
Main Authors: | Huaxiang Deng, Han Yu, Yanwu Deng, Yulan Qiu, Feifei Li, Xinran Wang, Jiahui He, Weiyue Liang, Yunquan Lan, Longjiang Qiao, Zhiyu Zhang, Yunfeng Zhang, Jay D. Keasling, Xiaozhou Luo |
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Format: | Article |
Language: | English |
Published: |
Wiley
2024-04-01
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Series: | Advanced Science |
Subjects: | |
Online Access: | https://doi.org/10.1002/advs.202306935 |
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