Variants Affecting the C-Terminal Tail of UNC93B1 Are Not a Common Risk Factor for Systemic Lupus Erythematosus

Variants Affecting the C-Terminal Tail of UNC93B1 Are Not a Common Risk Factor for Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a heterogeneous multifactorial disease. Upregulated TLR7 signaling is a known risk factor for SLE. Recently, it was shown that specific genetic variants in <i>UNC93B1</i> affect the physiological regulation of TLR7 signaling and cause characteristic...

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Bibliographic Details
Main Authors: Sarah Kiener, Camillo Ribi, Irene Keller, Carlo Chizzolini, Marten Trendelenburg, Uyen Huynh-Do, Johannes von Kempis, on behalf of Swiss SLE Cohort Study (SSCS), Tosso Leeb
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Genes
Subjects:
<i>Homo sapiens</i>
immunology
autoimmunity
candidate gene
TLR7 signaling
Online Access:https://www.mdpi.com/2073-4425/12/8/1268

Internet

https://www.mdpi.com/2073-4425/12/8/1268

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