Dl-3-n-Butylphthalide Promotes Remyelination and Suppresses Inflammation by Regulating AMPK/SIRT1 and STAT3/NF-κB Signaling in Chronic Cerebral Hypoperfusion

Dl-3-n-Butylphthalide Promotes Remyelination and Suppresses Inflammation by Regulating AMPK/SIRT1 and STAT3/NF-κB Signaling in Chronic Cerebral Hypoperfusion

Demyelination in vascular dementia (VD) is partly attributable to inflammation induced by chronic cerebral hypoperfusion (CCH). Remyelination contributes to the recovery of cognitive impairment by inducing the proliferation and differentiation of oligodendrocyte progenitor cells. It was previously r...

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Bibliographic Details
Main Authors: Meixi Li, Nan Meng, Xin Guo, Xiaoli Niu, Zhongmin Zhao, Wei Wang, Xiaohua Xie, Peiyuan Lv
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
chronic cerebral hypoperfusion
Dl-3-n-butylphthalide (NBP)
remyelination
inflammation
AMPK/SIRT1 pathway
STAT3/NF-κB pathway
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00137/full

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https://www.frontiersin.org/article/10.3389/fnagi.2020.00137/full

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