Solution Structure of Tubuliform Spidroin N-Terminal Domain and Implications for pH Dependent Dimerization

Solution Structure of Tubuliform Spidroin N-Terminal Domain and Implications for pH Dependent Dimerization

The spidroin N-terminal domain (NT) is responsible for high solubility and pH-dependent assembly of spider silk proteins during storage and fiber formation, respectively. It forms a monomeric five-helix bundle at neutral pH and dimerizes at lowered pH, thereby firmly interconnecting the spidroins. M...

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Bibliographic Details
Main Authors: Megija Šede, Jēkabs Fridmanis, Martins Otikovs, Jan Johansson, Anna Rising, Nina Kronqvist, Kristaps Jaudzems
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
spider silk
tubuliform spidroin
N-terminal domain
NMR structure
dimerization mechanism
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.936887/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.936887/full

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