Identification of a novel form of caspase-independent cell death triggered by BH3-mimetics in diffuse large B-cell lymphoma cell lines

Identification of a novel form of caspase-independent cell death triggered by BH3-mimetics in diffuse large B-cell lymphoma cell lines

Abstract BH3-mimetics represent promising anti-cancer agents in tumors that rely on the anti-apoptotic function of B-Cell Lymphoma 2 (BCL2) proteins, particularly in leukemia and lymphoma cells primed for apoptosis. Mechanistically, BH3-mimetics may displace pro-apoptotic binding partners thus induc...

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Bibliographic Details
Main Authors: Nahide Yildirim, Lakshmi Sarojam, Victoria M. Smith, Nadja M. Pieper, Marius Anders, Ross A. Jackson, Dominik C. Fuhrmann, Vinzenz Särchen, Daniela Brücher, Andreas Weigert, Martin J. S. Dyer, Meike Vogler
Format: Article
Language:English
Published: Nature Publishing Group 2024-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06652-3

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https://doi.org/10.1038/s41419-024-06652-3

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