The base excision repair pathway is required for efficient lentivirus integration.

An siRNA screen has identified several proteins throughout the base excision repair (BER) pathway of oxidative DNA damage as important for efficient HIV infection. The proteins identified included early repair factors such as the base damage recognition glycosylases OGG1 and MYH and the late repair...

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Bibliographic Details
Main Authors: Kristine E Yoder, Amy Espeseth, Xiao-hong Wang, Qingming Fang, Maria Teresa Russo, R Stephen Lloyd, Daria Hazuda, Robert W Sobol, Richard Fishel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3063173?pdf=render