Sesquiterpene Lactones Attenuate Paclitaxel Resistance Via Inhibiting MALAT1/STAT3/ FUT4 Axis and P-Glycoprotein Transporters in Lung Cancer Cells

Sesquiterpene Lactones Attenuate Paclitaxel Resistance Via Inhibiting MALAT1/STAT3/ FUT4 Axis and P-Glycoprotein Transporters in Lung Cancer Cells

Paclitaxel resistance is a challenging factor in chemotherapy resulting in poor prognosis and cancer recurrence. Signal transducer and activator of transcription factor 3 (STAT3), a key transcription factor, performs a critical role in cancer development, cell survival and chemoresistance, while its...

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Bibliographic Details
Main Authors: Yaming Ding, Zhang Zhen, Muhammad Azhar Nisar, Farman Ali, Riaz Ud Din, Muhammad Khan, Tafail Akbar Mughal, Gulzar Alam, Linlin Liu, Muhammad Zubair Saleem
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Pharmacology
Subjects:
paclitaxel resistance
STAT3
FUT4
P-gp
MALAT1
alantolactone
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.795613/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.795613/full

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