GluN2B S1303 phosphorylation by CaMKII or DAPK1: No indication for involvement in ischemia or LTP

GluN2B S1303 phosphorylation by CaMKII or DAPK1: No indication for involvement in ischemia or LTP

Summary: Binding of two different CaM kinases, CaMKII and DAPK1, to the NMDA-type glutamate receptor (NMDAR) subunit GluN2B near S1303 has been implicated in excitotoxic/ischemic neuronal cell death. The GluN2BΔCaMKII mutation (L1298A, R1300Q) is neuroprotective but abolishes only CaMKII but not DAP...

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Bibliographic Details
Main Authors: Jonathan E. Tullis, Olivia R. Buonarati, Steven J. Coultrap, Ashley M. Bourke, Erika L. Tiemeier, Matthew J. Kennedy, Paco S. Herson, K. Ulrich Bayer
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:iScience
Subjects:
Biochemistry
Molecular biology
Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221011822

Internet

http://www.sciencedirect.com/science/article/pii/S2589004221011822

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