Methotrexate-conjugated zinc oxide nanoparticles exert a substantially improved cytotoxic effect on lung cancer cells by inducing apoptosis

Methotrexate-conjugated zinc oxide nanoparticles exert a substantially improved cytotoxic effect on lung cancer cells by inducing apoptosis

In the current study, we report the synthesis of methotrexate-conjugated zinc oxide nanoparticles (MTX-ZnONPs) and their high efficacy against lung cancer cells. Conjugation of MTX with ZnONPs was authenticated by UV-vis spectroscopy, dynamic light scattering (DLS), Fourier-transform infrared (FTIR)...

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Bibliographic Details
Main Authors: Prakriti Mishra, Mohd Faizan Ali Ahmad, Lamya Ahmed Al-Keridis, Mohd Saeed, Nawaf Alshammari, Nadiyah M. Alabdallah, Rohit Kumar Tiwari, Afza Ahmad, Mahima Verma, Shireen Fatima, Irfan Ahmad Ansari
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Pharmacology
Subjects:
zinc oxide
nanoparticles
methotrexate
lung cancer
A549
reactive oxygen species
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1194578/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1194578/full

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