Mitosis-specific phosphorylation of amyloid precursor protein at Threonine 668 leads to its altered processing and association with centrosomes

Mitosis-specific phosphorylation of amyloid precursor protein at Threonine 668 leads to its altered processing and association with centrosomes

<p>Abstract</p> <p>Background</p> <p>Atypical expression of cell cycle regulatory proteins has been implicated in Alzheimer's disease (AD), but the molecular mechanisms by which they induce neurodegeneration are not well understood. We examined transgenic mice expr...

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Bibliographic Details
Main Authors: Judge Monique, Hornbeck Lisa, Potter Huntington, Padmanabhan Jaya
Format: Article
Language:English
Published: BMC 2011-11-01
Series:Molecular Neurodegeneration
Subjects:
Amyloid precursor protein
cell cycle
mitosis
kinases
APP phosphorylation
amyloid processing
Online Access:http://www.molecularneurodegeneration.com/content/6/1/80

Internet

http://www.molecularneurodegeneration.com/content/6/1/80

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