Anti-Inflammatory Effects of RTD-1 in a Murine Model of Chronic <i>Pseudomonas aeruginosa</i> Lung Infection: Inhibition of NF-κB, Inflammasome Gene Expression, and Pro-IL-1β Biosynthesis

Anti-Inflammatory Effects of RTD-1 in a Murine Model of Chronic <i>Pseudomonas aeruginosa</i> Lung Infection: Inhibition of NF-κB, Inflammasome Gene Expression, and Pro-IL-1β Biosynthesis

Vicious cycles of chronic airway obstruction, lung infections with <i>Pseudomonas aeruginosa</i>, and neutrophil-dominated inflammation contribute to morbidity and mortality in cystic fibrosis (CF) patients. Rhesus theta defensin-1 (RTD-1) is an antimicrobial macrocyclic peptide with imm...

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Bibliographic Details
Main Authors: Mansour A. Dughbaj, Jordanna G. Jayne, A Young J. Park, Timothy J. Bensman, Marquerita Algorri, Andre J. Ouellette, Michael E. Selsted, Paul M. Beringer
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Antibiotics
Subjects:
cystic fibrosis
inflammasome
inflammation
host defense peptides
Rhesus theta defensin-1
Online Access:https://www.mdpi.com/2079-6382/10/9/1043

Internet

https://www.mdpi.com/2079-6382/10/9/1043

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