Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy

Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy

Abstract Apolipoprotein (APOE) E4 isoform is a major risk factor of Alzheimer’s disease and contributes to metabolic and neuropathological abnormalities during brain aging. To provide insights into whether APOE4 genotype is related to tau-associated neurodegeneration, we have generated human P301S m...

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Bibliographic Details
Main Authors: Tristan Williams, Tim Bathe, Quan Vo, Patricia Sacilotto, Karen McFarland, Alejandra Jolie Ruiz, Gabriela P. Hery, Patrick Sullivan, David R. Borchelt, Stefan Prokop, Paramita Chakrabarty
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Acta Neuropathologica Communications
Subjects:
APOE
Phosphorylated tau
Aging
Survival
Immune response
Online Access:https://doi.org/10.1186/s40478-023-01581-2

Internet

https://doi.org/10.1186/s40478-023-01581-2

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